Dextran sulfate sodium salt, colitis grade (36,000 - 50,000)
Product Description
Dextran sulfate sodium salt, or DSS, is a synthetic sulfated branched polysaccharide derivative of dextran that has multiple uses in biomedical and clinical research (see table below). One important property of DSS is to triggers colitis in mice and rats when administered in drinking water. DSS binds to medium-chain-length fatty acids in the colon and induces intestinal inflammation. MP Premium Dextran Sulfate Sodium Salt (MW = 36,000–50,000) from MP Biomedicals is one of the most widely used product based on peer reviewed scientific publications. Over the past 15 years 3,000+ scientific publications have cited the use of our DSS.
Application Notes
Dextran sulfate sodium (DSS) is one of the most common and effective compounds used for inducing ulcerative colitis. The DSS colitis model has also been used extensively to study colon cancer developing in relation to colonic inflammation, such as that occurring in patients with long-standing ulcerative colitis.
MP Biomedicals offers the gold standard of colitis model creation reagents - colitis grade dextran sulfate sodium salt (36,000-50,000) and colonic carcinogen azoxymethane (AOM).
Because of its high efficacy, MP Biomedical DSS (Figure 1) is one of the most widely used DSS products in the scientific literature. Over the past 15 years more than 8,000 scientific publications have cited the use of MP Biomedicals’ DSS products.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Acute/ Chronic Ulcerative Colitis Model Induction, Chronic Colitis Associated Colon Cancer Model Induction
| SKU | 02160110-CF |
| Alternate Names | DSS, Dextran Sodium Sulfate |
| Application Notes |
Dextran sulfate sodium (DSS) is one of the most common and effective compounds used for inducing ulcerative colitis. The DSS colitis model has also been used extensively to study colon cancer developing in relation to colonic inflammation, such as that occurring in patients with long-standing ulcerative colitis. MP Biomedicals offers the gold standard of colitis model creation reagents - colitis grade dextran sulfate sodium salt (36,000-50,000) and colonic carcinogen azoxymethane (AOM). Because of its high efficacy, MP Biomedical DSS (Figure 1) is one of the most widely used DSS products in the scientific literature. Over the past 15 years more than 8,000 scientific publications have cited the use of MP Biomedicals’ DSS products. |
| Base Catalog Number | 160110 |
| Boiling Point | 310 ° C |
| CAS # | 9011-18-1 |
| Grade | Colitis Grade |
| Melting Point | 92 ° C |
| Molecular Weight | 36,000 - 50,000 Da |
| Personal Protective Equipment | Eyeshields, Gloves, respirator filter |
| pH | (1% aqueous solution) 5-7.11 |
| References |
Kinchen, J. Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease. Cell. 2018, 175, 372-386. Mahalhal , A. Oral iron exacerbates colitis and influences the intestinal microbiome, PLOS ONE. 2018, 13, e0202460. Dokoshi, T. Hyaluronidase inhibits reactive adipogenesis and inflammation of colon and skin. JCI Insight. 2018, 3, e12307. Zhu, H. RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer. J. Exp. Clin. Cancer Res. 2017, 36, 2. Monticelli, L. IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions. PNAS. 2015, 112, 10762-10767. |
| RTECS Number | HH9290000 |
| Solubility | 100 mg/mL (decreases with increasing of MW) |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| Vapor Pressure | 2.6 x 10-4 mm Hg at 25 ° ° C (Estimated) |