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Arg-Gly-Asp-Ser, 2 mg

Arg-Gly-Asp-Ser, 2 mg

NZ$123.45

SKU: 0215305302

Synonyms
RGDS
CAS Number:
91037-65-9
Molecular Formula:
C15H27N7O8
Molecular Weight:
433.4
MDL Number:
MFCD00076452
Packaging size:
2 mg
Product Description

The tetrapeptide Arg-Gly-Asp-Ser (RGDS) is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRK cells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.

Application Notes

The tetrapeptide Arg-Gly-Asp-Ser (RGDS) has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor β1 (TGFbeta1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages. It inhibits fibronectin binding to platelets.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Specifications
SKU 0215305302
Alternate Names RGDS
Application Notes The tetrapeptide Arg-Gly-Asp-Ser (RGDS) has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor β1 (TGFbeta1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages. It inhibits fibronectin binding to platelets.
Base Catalog Number 15305302
CAS # 91037-65-9
Molecular Formula C15H27N7O8
Molecular Weight 433.4
Pack Size 2 mg
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Solubility Soluble in water (1 mg/mL - clear colourless solution).
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Documents

Certificates of Analysis

Certificates of Analysis
English (United States)
Certificates of Analysis
English (United States)

Datasheets

Datasheets
English (United States)