The Penetratin-Arg peptide is a transfection reagent derived from the third helix of the homeodomain of the Antennapedia protein (pAntp) from Drosophila melanogaster. Penetratin-Arg is a 16 amino acid cell-penetrating peptide where the lysine residues in Penetratin have been substituted with Arginines.
Application Notes
Penetratin-Arg peptide is a novel tool for peptide and siRNA delivery. It has been successfully used to internalize covalently attached peptides, oligonucleotides, and siRNA. It is sold ready for coupling to peptides or oligonucleotides containing thiol (-SH) functions.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Transfection, Drug Delivery
| SKU | 11PENA1000 |
| Alternate Names | Transfection Reagent, H-Arg-Gln-Ile-Arg-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Arg-Trp-Arg-Arg-OH, RQIRIWFQNRRMRWRR |
| Application Notes | Penetratin-Arg peptide is a novel tool for peptide and siRNA delivery. It has been successfully used to internalize covalently attached peptides, oligonucleotides, and siRNA. It is sold ready for coupling to peptides or oligonucleotides containing thiol (-SH) functions. |
| Base Catalog Number | PENA0500 |
| Format | Powder |
| Media Type | Transfection reagents |
| Molecular Weight | 2359 |
| Pack Size | 1 mg |
| Personal Protective Equipment | Personal-protective-equipment: If working with biological, toxic, hazardous or infectious samples; Hand protection: Latex, Nitrile or other plastic material gloves. Skin and body protection: Labcoat and sleves. Eye protection: Safety glasses with side-shields Hygiene measures: Handle in accordance with good industrial hygiene and safety practice. |
| References | 1. Damante G. et al., (1996) EMBO J. 15, 4992-500||2. Dorn A. et al. (1994) Pharmac. Ther. 61,155-183||3. Prochiantz A. (1996) Curr. Opin. Neurobiol. 6, 629-634||4. Derossi D. et al., (1996) J Biol. Chem. 271,18188-18193||5. Brian R et al., (2004) J. Exp. Med 4,547-557||6. Davidson T.J. et al., (2004) J. of Neuroscience. 24 (45), 10040-10046 |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
![MP COA [PENA0500] lot ID: 840Q4460R2](https://www.mpbio.com/static/version1781469166/frontend/Mpbio/luma/en_US/images/document.png "MP COA [PENA0500] lot ID: 840Q4460R2")
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