Chloroquine diphosphate salt

Name: Chloroquine diphosphate salt
SKU: 02193919-CF
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SKU: 02193919-CF

Key features and details

Antibiotic
Antimalarial compound

Synonyms

Chloroquinone Phosphate;N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt

CAS Number:

50-63-5

Molecular Formula:

C18H26N3Cl • 2H3PO4

Molecular Weight:

515.865 g/mol

Beilstein Registry Number:

4223142

EC Number:

200-055-2

MDL Number:

MFCD00069852

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Product Description

Chloroquine Diphosphate Salt

Application Notes

Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. DNA intercalator. Also used to increase transfection efficiency.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Specifications

SKU	02193919-CF
Alternate Names	Chloroquinone Phosphate;N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Application Notes	Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. DNA intercalator. Also used to increase transfection efficiency.
Base Catalog Number	193919
Beilstein Registry Number	4223142
Biochemical Physiological Actions	Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labeling of MRP by quinoline-based photoactive drug IAAQ (N-[4-[1-hydroxy-2-(dibutylamino)ethyl]quinolin-8-yl]-4-azidosalicylamide).
CAS #	50-63-5
EC Number	200-055-2
Hazard Statements	H302
Melting Point	87 deg C
Molecular Formula	C18H26N3Cl • 2H3PO4
Molecular Weight	515.865 g/mol
Personal Protective Equipment	Dust mask type , Eyeshields, Gloves
pKa	4.0 - 5.0
Potency	8.4 and 10.8 (for chloroquine base at 20 °C)
RTECS Number	VB2450000
Solubility	VERY SLIGHTLY SOL IN <a class="pubchem-internal-link CID-962" href="https://pubchem.ncbi.nlm.nih.gov/compound/WATER">WATER</a>; SOL IN DIL ACIDS, <a class="pubchem-internal-link CID-6212" href="https://pubchem.ncbi.nlm.nih.gov/compound/CHLOROFORM">CHLOROFORM</a>, ETHER
Source	Soluble in water. Practically insoluble in alcohol; benzene; chloroform and ether.
Storage	BIOCHEMICALS
Unit Definition	Chloroquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 µM
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure	5.0X10-9 mm Hg at 25 deg C (est)