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Tobramycin has been used:• to study the effect of tobramycin on bacteriophage infected biofilms• to study the effects of antibiotics on Pseudomonas aeruginosa strain• as a comparator antibiotic
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|Alternate Names||Nebramycin Factor 6; O-[3-Amino-3-deoxy-a-D-glucopyranosyl-(1?6)]-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribohexopyranosyl-(1?4)]-2-deoxy-D-streptamine|
|Application Notes||Tobramycin has been used:• to study the effect of tobramycin on bacteriophage infected biofilms• to study the effects of antibiotics on Pseudomonas aeruginosa strain• as a comparator antibiotic|
|Base Catalog Number||199697|
|Beilstein Registry Number||1357507|
|Biochemical Physiological Actions||Tobramycin is an aminoglycoside. Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding. Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16S rRNA (ribosomal RNA). It inhibits translocation and elicits miscoding.Tobramycin is used to treat Pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections. It is a potential therapy for sinus infections.|
|Molecular Weight||467.52 g/mol|
|Safety Symbol||GHS08, GHS07|
|Solubility||Water Solubility1000 mg/ml|
|Vapor Pressure||2.37X10-21 mm Hg at 25 deg C (est)|