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Tamoxifen, citrate salt

Tamoxifen, citrate salt

Synonyms [Z]-1-[p-Dimethylaminoethoxyphenyl]-1,2-diphenyl-1-butene; (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; ICI 47699; trans-Tamoxifen; Z-Tamoxifen; (Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine; trans-1-(p-b- Dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-ene citrate; Kessar; Tamofen; Terimon; ICI 46474; Z-Tamoxifen Citrate

CAS Number: 54965-24-1 Molecular Formula: C26H29NO·C6H8O7 Molecular Weight: 563.647 g/mol

EC Number: 259-415-2 MDL Number: MFCD00058321

SKU 02156739-CF
$40.60
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Description

Product Description

Tamoxifen Citrate Salt

Application Notes

Tamoxifen has been shown to protect bone from estrogen-deficiency bone loss and lower plasma cholesterol in the rat. A 10 µM solution has exhibited fungicidal activity (optimal pH 7.5) against yeast cells of C. albicans. It has been implemented in liver carcinogenesis in rats. Other actions of tamoxifen are: Reduction of plasma levels of insulin-like growth factor; Induction of cells surrounding cancer cells to secrete transforming growth factor b; Inhibition of membrane lipid peroxidation probably by decreasing membrane fluidity.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Protein kinase C inhibitor | Induces apoptosis | Mixed estrogen agonists/antagonists

Specifications
SKU 02156739-CF
Alternate Names [Z]-1-[p-Dimethylaminoethoxyphenyl]-1,2-diphenyl-1-butene; (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine; ICI 47699; trans-Tamoxifen; Z-Tamoxifen; (Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine; trans-1-(p-b- Dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-ene citrate; Kessar; Tamofen; Terimon; ICI 46474; Z-Tamoxifen Citrate
Application Notes Tamoxifen has been shown to protect bone from estrogen-deficiency bone loss and lower plasma cholesterol in the rat. A 10 µM solution has exhibited fungicidal activity (optimal pH 7.5) against yeast cells of C. albicans. It has been implemented in liver carcinogenesis in rats. Other actions of tamoxifen are: Reduction of plasma levels of insulin-like growth factor; Induction of cells surrounding cancer cells to secrete transforming growth factor b; Inhibition of membrane lipid peroxidation probably by decreasing membrane fluidity.
Base Catalog Number 156739
Biochemical Physiological Actions Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
CAS # 54965-24-1
EC Number 259-415-2
Format Powder
Hazard Statements H302-H350-H360
Molecular Formula C26H29NO·C6H8O7
Molecular Weight 563.647 g/mol
Personal Protective Equipment Eyeshields, full-face particle respirator, Gloves, respirator cartridge respirator filter
pKa approximately 8.854; approximately 6.9 (in Triton® X-100)(Lit.)
RTECS Number KH2387000
Safety Symbol GHS07, GHS08
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.