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Spermine, ≥85%, 1 g

Spermine, ≥85%, 1 g

Synonyms N,N'-bis[3-Aminopropyl]-1,4-butanediamine; Gerontine; Musculamine; Neuridine

CAS Number: 71-44-3 Molecular Formula: C10H26N4 Molecular Weight: 202.3

Beilstein Registry Number: 1750791 EC Number: 200-754-2 MDL Number: MFCD00008215

Packaging size: 1 g

SKU 0215206901
$64.50
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Description

Product Description

Spermine is a naturally occuring polyamine that occurs in all eukaryotes, but is rare in prokaryotes. It is essential for cell growth in both normal and neoplastic tissue. Spermine is formed through the addition of a aminopropyl group to spermidine by spermine synthase. Spermine is strongly basic in character, and in aqueous solution at physiological pH, all of its amino groups will be positively charged.

Application Notes

Spermine is commonly used in molecular biology and biochemistry research. The polycationic character of spermine in solution allows for its use in the precipitation of DNA of >100 base pairs in length from low salt aqueous buffers, and for the isolation of DNA from pulse field gels. Spermine has also been utilized in chromosome isolation and in the aggregation of chromatin. It may be used as a building block for the preparation of gene transfer agents. The complexation of spermine with DNA to form particles with diameter <100 nm has been studied. Spermine has been used in the crystallization of DNA.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Chromosome isolation | Preparation of gene transfer agents | Neuroprotective effect

Specifications
SKU 0215206901
Alternate Names N,N'-bis[3-Aminopropyl]-1,4-butanediamine; Gerontine; Musculamine; Neuridine
Application Notes Spermine is commonly used in molecular biology and biochemistry research. The polycationic character of spermine in solution allows for its use in the precipitation of DNA of >100 base pairs in length from low salt aqueous buffers, and for the isolation of DNA from pulse field gels. Spermine has also been utilized in chromosome isolation and in the aggregation of chromatin. It may be used as a building block for the preparation of gene transfer agents. The complexation of spermine with DNA to form particles with diameter <100 nm has been studied. Spermine has been used in the crystallization of DNA.
Base Catalog Number 15206901
Beilstein Registry Number 1750791
Biochemical Physiological Actions Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Boiling Point 141-142 °C at 0.5 mm Hg (Lit.)
CAS # 71-44-3
EC Number 200-754-2
Flash Point 110 °C(Lit.)
Hazard Statements H314
Melting Point 28-30 °C
Molecular Formula C10H26N4
Molecular Weight 202.3
Pack Size 1 g
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
Purity ≥85%
RTECS Number EJ7175000
Safety Symbol GHS05
Solubility Soluble in water (1% w/v), lower alcohol, chloroform; practically insoluble in ether, benzene, petroleum ether.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.