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Pyrimethamine

Pyrimethamine

Synonyms 5-[4-Chlorophenyl]-6-ethyl-2,4-pyrimidinediamine; 2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine; Chloridin

CAS Number: 58-14-0 Molecular Formula: C12H13N4Cl Molecular Weight: 248.714 g/mol

Beilstein Registry Number: 219864 EC Number: 200-364-2 MDL Number: MFCD00057350

SKU 02194180-CF
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Description

Product Description

Pyrimethamine

Application Notes

Pyrimethamine is a medication used for protozoal infections. It is commonly used as an antimalarial drug, and is also used (combined with sulfadiazine) in the treatment of Toxoplasma gondii infections in immunocompromised patients, such as HIV-positive individuals. It is also currently being evaluated in clinical trials as a treatment for ALS.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antiprotozoal compound

Specifications
SKU 02194180-CF
Alternate Names 5-[4-Chlorophenyl]-6-ethyl-2,4-pyrimidinediamine; 2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine; Chloridin
Application Notes Pyrimethamine is a medication used for protozoal infections. It is commonly used as an antimalarial drug, and is also used (combined with sulfadiazine) in the treatment of Toxoplasma gondii infections in immunocompromised patients, such as HIV-positive individuals. It is also currently being evaluated in clinical trials as a treatment for ALS.
Base Catalog Number 194180
Beilstein Registry Number 219864
Biochemical Physiological Actions Pyrimethamine interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR). Tetrahydrofolic acid is needed for DNA and RNA synthesis in many species, including protozoa. It has also found to inhibit SOD1, a key protein involved in ALS.
CAS # 58-14-0
EC Number 200-364-2
Format Powder
Hazard Statements H302
Melting Point 451 to 453° F (capillary) (NTP, 1992)
Molecular Formula C12H13N4Cl
Molecular Weight 248.714 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Faceshields, Gloves
RTECS Number UV8140000
Safety Symbol GHS07
Solubility >37.3 [ug/mL]
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure 1.32X10-8 mm Hg at 25 deg C (est)