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Prostaglandin i2 sodium salt
Prostaglandin I2 Sodium Salt
Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Potent inhibitor of platelet aggregation
|Alternate Names||PG-I2Na; Prostacycline; (5Z, 9α, 11α, 13E, 15S)-6,9α-epoxy-11α,15-dihydroxy-prosta-5,13-dien-1-oic acid, monosodium salt; Prostacyclin, sodium salt; Epoprostenol sodium salt; (5Z,9α,11α,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt|
|Application Notes||Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.|
|Base Catalog Number||151969|
|Beilstein Registry Number||6472195|
|Biochemical Physiological Actions||Prostaglandin I2 sodium salt stimulats platelet adenylyl cyclase. Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.|
|Half Life||Solutions of PGI2 at physiologic pH and room temperature will have a half-life from 1 to 12 minutes depending on buffer concentration. Half-life under physiological conditions is 2 minutes.|
|Molecular Weight||374.453 g/mol|
|Personal Protective Equipment||Dust mask, Eyeshields, Gloves|
|Usage Statement||Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.|