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Paclitaxel has been used as a component of the dechorionation buffer for Gryllus bimaculatus eggs. Paclitaxel has also been used for studying its effect on the movement of all-trans retinoic acid (ATRA) differentiated NB4 cells.
Anti-neoplastic agent | Anti-mitotic drug | Antitumor agent | Antileukemic agent
|Alternate Names||Taxol® (Bristol-Myers Squibb); Taxol A; NSC 125973|
|Application Notes||Paclitaxel has been used as a component of the dechorionation buffer for Gryllus bimaculatus eggs. Paclitaxel has also been used for studying its effect on the movement of all-trans retinoic acid (ATRA) differentiated NB4 cells.|
|Base Catalog Number||193532|
|Beilstein Registry Number||1420457|
|Biochemical Physiological Actions||Antitumor and antileukemic agent which lowers the critical concentration for tubulin polymerization and reversibly binds to tubulin prohibiting depolymerization; binds to the N-terminal region of beta-tubulin and promotes the formation of highly stable microtubles that resist depolymerization, thus preventing normal cell division and arresting the cell cycle at the G2-M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway in the early phase followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A or of Raf-1 kinase, that results in phosphorylation of Bcl-2.|
|Melting Point||415 to 421Â° F (NTP, 1992)|
|Molecular Weight||853.918 g/mol|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter|
|Safety Symbol||GHS05, GHS07, GHS08|
|Solubility||<h5 class="minor-section-title">Water Solubility</h5>Insoluble|
|Source||Taxus brevifolia(Pacific Yew Bark)|