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Methotrexate

Methotrexate

$37.60
Methotrexate

SKU: 02102299-CF

Synonyms
Amethopterin; N-[4-[[(2,4-Diamino-6-pteridinyl) methyl] methylamino] benzoyl]-L- glutamic acid; 4-amino-N10-methylpteroylglutamic acid; 4-amino-10-methylfolic acid; methylaminopterin; MTX; CL-14377; Emtexate; Ledertrexate; A-Methopterin; Rheumatrex
CAS Number:
59-05-2
Molecular Formula:
C20H22N8O5
Molecular Weight:
454.447 g/mol
EC Number:
200-413-8
MDL Number:
MFCD00064370
Product Description

Methotrexate

Application Notes

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites. Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Anti-tumor studies.

Specifications
SKU 02102299-CF
Alternate Names Amethopterin; N-[4-[[(2,4-Diamino-6-pteridinyl) methyl] methylamino] benzoyl]-L- glutamic acid; 4-amino-N10-methylpteroylglutamic acid; 4-amino-10-methylfolic acid; methylaminopterin; MTX; CL-14377; Emtexate; Ledertrexate; A-Methopterin; Rheumatrex
Application Notes Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites. Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Base Catalog Number 102299
Biochemical Physiological Actions Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.
CAS # 59-05-2
EC Number 200-413-8
Format Powder
Grade USP
Melting Point 365 to 399° F (decomposes) (NTP, 1992)
Molecular Formula C20H22N8O5
Molecular Weight 454.447 g/mol
Optical Rotation +19° to +24°
Purity ≥98%
RTECS Number MA1225000
Solubility less than 1 mg/mL at 66° F (NTP, 1992)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure 2.1X10-19 mm Hg at 25 deg C /Estimated/
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