Chlorhexidine

Application Notes

An intermediate for the production of chlorhexidine salts which are used as an antiseptic and disinfectant agent. It is effective against a wide range of bacteria, some fungi and some viruses, and an agent for the prevention of gingivitis. Commercial ophthalmic products have used this agent to replace thimerosal as a preservative; however, it can cause skin irritation. It ia used in analytical standard for pharmaceuticals.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antiseptic | Disinfectant agent | Chemical Synthesis

SKU	02191358-CF
Alternate Names	1,6-Di(N-p-chlorophenyl- diguanido) hexane ; 1,6-Di(N-p-Chlorophenyldiguanido) hexane; 1,1'-Hexamethylene bis[5-(4- chlorophenyl) biguanide]
Application Notes	An intermediate for the production of chlorhexidine salts which are used as an antiseptic and disinfectant agent. It is effective against a wide range of bacteria, some fungi and some viruses, and an agent for the prevention of gingivitis. Commercial ophthalmic products have used this agent to replace thimerosal as a preservative; however, it can cause skin irritation. It ia used in analytical standard for pharmaceuticals.
Base Catalog Number	191358
Beilstein Registry Number	2826432
CAS #	55-56-1
EC Number	200-238-7
Format	Powder
Hazard Statements	H315-H319-H334-H335-H410
Melting Point	258-260
Molecular Formula	C22H30Cl2N10
Molecular Weight	505.452 g/mol
Personal Protective Equipment	Dust mask , Eyeshields, Faceshields, Gloves
RTECS Number	DU1925000
Safety Symbol	GHS07, GHS08, GHS09
Solubility	Water Solubility800 mg/L (at 20 °C)
Sterilization of Solutions	Dilute solutions of chlorhexidine (<1.0% w/v) may be sterilized by autoclaving at 115 °C for 30 minutes or at 121-123 °C for 15 minutes. Autoclaving of solutions greater than 1.0% can result in the formation of insoluble residues and is therefore unsuitable. If sterile solutions are required at such high concentrations, then filtration through a 0.22 um membrane filter is recommended. Dilute chlorhexidine solutions may be stored at room temperature, and a shelf life of at least 1 year can be expected, provided that the packaging is adequate. Prolonged exposure to high temperature or light is to be avoided because this can adversely affect the stability of chlorhexidine solutions. All dilute solutions to be stored should be either heat-treated (sterilized or pasteurized) or chemically preserved (4 % isopropanol or 7 % ethanol) to eliminate the possibility of microbial contamination. .
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure	1.98X10-14 mm Hg at 25 deg C (est)