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Product Description
Hemin Chloride
Application Notes
Hemin is used in the management of porphyria attacks, particularly in acute intermittent porphyria.It may be used to study the expression and repression of heme oxygenase 1 (HO-1) as well as the activity of HO-1.Hemin is used for the following applications:• To study bacterial strains and growth conditions• Used in short-term colony assays (the culture medium consists of hemin along with other components)• Cell transfections• It may be used in ß-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Specifications
| SKU | 02198820-CF |
| Alternate Names | Hemin Chloride; Chloroferriprotoporphyrin; Chlorohemin; Chloro(protoprophyrinato) iron (III); Ferriprotoporphyrin IX chloride; Hematin hydrochloride; Protohemin IX; (SP-5-13)-Chloro [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)- N21, N22, N23, N24] ferrate(2-) dihydrogen; Chloro [dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2, 18-porphinedipropionato (2-)]iron; 1,3,5,8-tetramethyl-2,4-divinylporphine-6,7- dipropionic acid ferrichloride; Teichmann's crystals; Ferriheme chloride |
| Application Notes | Hemin is used in the management of porphyria attacks, particularly in acute intermittent porphyria.It may be used to study the expression and repression of heme oxygenase 1 (HO-1) as well as the activity of HO-1.Hemin is used for the following applications:• To study bacterial strains and growth conditions• Used in short-term colony assays (the culture medium consists of hemin along with other components)• Cell transfections• It may be used in ß-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin. |
| Base Catalog Number | 198820 |
| Beilstein Registry Number | 5229914 |
| Biochemical Physiological Actions | Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders. Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae. |
| CAS # | 16009-13-5 |
| EC Number | 240-140-1 |
| Format | Powder |
| Molecular Formula | C34H32ClFeN4O4 |
| Personal Protective Equipment | Eyeshields, Gloves,respirator filter |
| Preparation Method | Typically prepared by heating a hemoglobin solution with acetic acid and sodium chloride. |
| Source | Porcine |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
Documents
![MP COA [198820] lot ID: 1242J](https://www.mpbio.com/static/version20220125073033Z/frontend/Mpbio/default/en_US/images/document.png "MP COA [198820] lot ID: 1242J")