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Plasminogen
Product Description
Plasminogen
Application Notes
Plasminogen is a single-chain glycoprotein found in human plasma and extracellular fluid. Certain activators, such as tissue plasminogen activator (tPA), convert plasminogen to its active form, plasmin. Plasminogen has been used to study its conversion into plasmin.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Specifications
SKU | 02191342-CF |
Alternate Names | Profibrinolysin |
Application Notes | Plasminogen is a single-chain glycoprotein found in human plasma and extracellular fluid. Certain activators, such as tissue plasminogen activator (tPA), convert plasminogen to its active form, plasmin. Plasminogen has been used to study its conversion into plasmin. |
Base Catalog Number | 191342 |
Biochemical Physiological Actions | Plasminogen is the inactive precursor of the protease plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration. Plasmin cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. It is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β). |
CAS # | 9001-91-6 |
EC Number | 232-641-9 |
Format | Solid |
Personal Protective Equipment | Eyeshields, Gloves,respirator filter |
Purity | ≥95% |
Source | Human plasma |
Unit Definition | the amount of enzyme which will hydrolyze 1 µmol of N-tosyl-L-arginine ester in 30 minutes at 37°C at pH 8.0. |
Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
Citations
Documents
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Certificate of Analysis
Datasheet
Datasheet