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Product Description
Cyclophosphamide Monohydrate
Application Notes
Cyclophosphamide monohydrate used for induction chemotherapy to study predictive and prognostic values of tumor MGMT gene expression, to study its effects on apoptosis and cell cycle progression and its cardiotoxicity during pretransplant conditioning in blood stem cell transplantation has been reported.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Cancer research tool
Specifications
| SKU | 02150749-CF |
| Alternate Names | Endoxan A; Cytoxan; 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; N,N-bis(2-Chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate; 2-[bis(2-Chloroethyl) amino] tetrahydro-2H-1,3,2-oxazophosphorine 2-oxide monohydrate; 1-bis(2-Chloroethyl) amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate; bis(2-Chloroethyl) phosphamide cyclic propanolamide ester monohydrate; bis(2-Chloroethyl)phosphoramide cyclic propanolamide ester monohydrate; N,N-bis(b-Chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate; N,N-bis(b-Chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate; Cyclophosphane; Cytophosphane; B-518 |
| Application Notes | Cyclophosphamide monohydrate used for induction chemotherapy to study predictive and prognostic values of tumor MGMT gene expression, to study its effects on apoptosis and cell cycle progression and its cardiotoxicity during pretransplant conditioning in blood stem cell transplantation has been reported. |
| Base Catalog Number | 150749 |
| Beilstein Registry Number | 4678992 |
| Biochemical Physiological Actions | Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. |
| CAS # | 6055-19-2 |
| EC Number | 200-015-4 |
| Flash Point | greater than 230° F (NTP, 1992) |
| Hazard Statements | H301-H350 |
| Melting Point | 121 to 127° F (NTP, 1992) |
| Molecular Formula | C7H15Cl2N2O2P · H2O |
| Molecular Weight | 279.098 g/mol |
| Personal Protective Equipment | Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter |
| Purity | ≥98% |
| RTECS Number | RP6157750 |
| Safety Symbol | GHS06, GHS08 |
| Solubility | 10 to 50 mg/mL at 73° F (NTP, 1992) |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
Documents
![MP COA [150749] lot ID: 4576A](https://www.mpbio.com/static/version20220125073033Z/frontend/Mpbio/default/en_US/images/document.png "MP COA [150749] lot ID: 4576A")