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Nitrofurantoin

Nitrofurantoin

$61.65

Key features and details

Nitrofurantoin

SKU: 02155881-CF

Synonyms
N-(5-Nitro-2-furfurylidene)-1-aminohydantoin;Furadoxyl; Nitrofurantoine
CAS Number:
67-20-9
Molecular Formula:
C8H6N4O5
Molecular Weight:
238.159 g/mol
Beilstein Registry Number:
893207
EC Number:
200-646-5
MDL Number:
MFCD00003224
Product Description

Nitrofurantoin

Application Notes

Nitrofurantoin is a nitrofuran antibiotic that is used as a substrate for bacterial nitrofuran reductase to study the interactions of active metabolites with DNA, ribosomal proteins and metabolic and pro-oxidant processes. It is used to study nitrofurantoin - induced toxicity and antiobiotic resistance.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibiotic

Specifications
SKU 02155881-CF
Alternate Names N-(5-Nitro-2-furfurylidene)-1-aminohydantoin;Furadoxyl; Nitrofurantoine
Application Notes Nitrofurantoin is a nitrofuran antibiotic that is used as a substrate for bacterial nitrofuran reductase to study the interactions of active metabolites with DNA, ribosomal proteins and metabolic and pro-oxidant processes. It is used to study nitrofurantoin - induced toxicity and antiobiotic resistance.
Base Catalog Number 155881
Beilstein Registry Number 893207
Biochemical Physiological Actions Nitrofurantoin is activated by bacterial flavoproteins (nitrofuran reductase) to actively reduce reactive intermediates that modulate and damage ribosomal proteins or other macromolecules, such as DNA. This inhibits DNA, RNA, protein, and cell wall synthesis which causes cell death. Nitrofurantoin has a low resistance potential that is rapidly metabolized by mammals and is active against both Gram-positive and Gram-negative bacteria. It is also a pro-oxidant that is cytotoxic due to the generation of intracellular H2O 2. It is an inhibitor of glutathione reductase. Nitrofurantoin produces hepatotoxicity caused by the redox cycling of the nitro group and its radical anion which leads to oxidative stress.
CAS # 67-20-9
EC Number 200-646-5
Extinction Coefficient E1% = 776 (H2O) (Lit.)
Format Powder
Hazard Statements H302-H317-H334
Melting Point 514° F (decomposes) (NTP, 1992)
Molecular Formula C8H6N4O5
Molecular Weight 238.159 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Faceshields, Gloves
RTECS Number MU2800000
Safety Symbol GHS07, GHS08
Solubility >35.7 [ug/mL]
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Documents

Certificate of Analysis (COA)

Datasheet

Datasheet

Safety Data Sheets

English (United States)