Cart
 
In Stock

Chloramphenicol, phytopure™

Chloramphenicol, phytopure™

$35.30

Key features and details

CAS Number: 56-75-7

SKU: 02190321-CF

Synonyms
D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide; D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol; D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide; Chloromycetin; Anacetin; Chlomin; Embacetin; Mychel; veticol
CAS Number:
56-75-7
Molecular Formula:
C11H12Cl2N2O5
Molecular Weight:
323.20
Beilstein Registry Number:
2225532
EC Number:
200-287-4
MDL Number:
MFCD00078159
Product Description

A synthetic antibiotic first isolated from Streptomyces venezuelae. It is effective against gram-positive and gram-negative bacteria. It interferes with translation on the 50S ribosomal subunit at the peptidyl transferase step (elongation inhibition) and inhibits mitochondrial and chloroplast protein synthesis.

Application Notes

Chloramphenicol and several analogues inhibited DNA synthesis in Ehrlich Ascites cells under aerobic and anaerobic conditions in the presence and absence of glucose. It is used mainly for opthalmic (eye drops) and veterinary purposes. Used as a seletion agent for transformed cells containing chloramphenicol resistance genes.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Specifications
SKU 02190321-CF
Alternate Names D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide; D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol; D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide; Chloromycetin; Anacetin; Chlomin; Embacetin; Mychel; veticol
Application Notes Chloramphenicol and several analogues inhibited DNA synthesis in Ehrlich Ascites cells under aerobic and anaerobic conditions in the presence and absence of glucose. It is used mainly for opthalmic (eye drops) and veterinary purposes. Used as a seletion agent for transformed cells containing chloramphenicol resistance genes.
Base Catalog Number 190321
Beilstein Registry Number 2225532
Biochemical Physiological Actions Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.
Boiling Point Sublimes
CAS # 56-75-7
EC Number 200-287-4
Extinction Coefficient (278 nm) = 298 (water) (Lit.)
Format Powder
Hazard Statements H350
Melting Point 171
Molecular Formula C11H12Cl2N2O5
Molecular Weight 323.20
Optical Rotation (c=5 ethanol)+18 ° ± 5 °
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
pH NEUTRAL TO LITMUS
Purity >99%
RTECS Number AB6825000
Safety Symbol GHS08
Solubility Water Solubility2500 mg/L (at 25 °C)
Typical Working Concentration 5 -20 µg/mL
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure 1.7X10-12 mm Hg at 25 deg C /Estimated/
Citations
Documents

Certificate of Analysis

Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis

Datasheet

Datasheet

Material Safety Datasheet

Material Safety Datasheet
en_AE
Material Safety Datasheet
de_AT
Material Safety Datasheet
fr_BE
Material Safety Datasheet
en_CA
Material Safety Datasheet
de_CH
Material Safety Datasheet
fr_CH
Material Safety Datasheet
cn_ZH
Material Safety Datasheet
de_DE
Material Safety Datasheet
es_ES
Material Safety Datasheet
fi_FI
Material Safety Datasheet
fr_FR
Material Safety Datasheet
tw_ZH
Material Safety Datasheet
en_ID
Material Safety Datasheet
en_IE
Material Safety Datasheet
en_IN
Material Safety Datasheet
ja_JP
Material Safety Datasheet
de_LI
Material Safety Datasheet
de_LU
Material Safety Datasheet
en_MT
Material Safety Datasheet
es_MX
Material Safety Datasheet
no_NO
Material Safety Datasheet
pt_PT
Material Safety Datasheet
sv_SE
Material Safety Datasheet
en_US

Brochures