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Amphotericin B

Amphotericin B

$56.70

Key features and details

Amphotericin B

SKU: 02195043-CF

Synonyms
Amphomoronal; Amphotericine B; Amphozone; Fungilin; Fungisone; Fungizone
CAS Number:
1397-89-3
Molecular Formula:
C47H73NO17
Molecular Weight:
924.091 g/mol
Beilstein Registry Number:
78342
EC Number:
215-742-2
MDL Number:
MFCD00877763
Product Description

Amphotericin B

Application Notes

Amphotericin B is used to study the affects of the influx of calcium on antifungal activity and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers . It is also commonly used in tissue culture as an antifungal supplement.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibiotic

Specifications
SKU 02195043-CF
Alternate Names Amphomoronal; Amphotericine B; Amphozone; Fungilin; Fungisone; Fungizone
Application Notes Amphotericin B is used to study the affects of the influx of calcium on antifungal activity and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers . It is also commonly used in tissue culture as an antifungal supplement.
Base Catalog Number 195043
Beilstein Registry Number 78342
Biochemical Physiological Actions Amphotericin B is a polyene antifungal antibiotic from Streptomyces. It has an affinity for sterols, primarily ergosterols, of fungal cell membranes. It forms channels in the membranes, causing small molecules to leak out which contributes to cell death. Antimicrobial spectrum: fungi and yeast. Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out. Antimicrobial spectrum: fungi and yeast
CAS # 1397-89-3
EC Number 215-742-2
Hazard Statements H315-H319-H335
Melting Point greater than 338° F (decomposes) (NTP, 1992)
Molecular Formula C47H73NO17
Molecular Weight 924.091 g/mol
Personal Protective Equipment dust mask , Eyeshields, Gloves
pKa 5.5 and 10.0.(Lit.)
Potency >800 µg/mg
RTECS Number BU2625000
Safety Symbol GHS07
Solubility less than 1 mg/mL at 70° F (NTP, 1992)
Source Streptomyces sp.
Sterilization of Solutions Sterilization of solutions should be by filtration through teflon membrane filters; Amphotericin B should not be gamma irradiated or autoclaved.
Typical Working Concentration recommended concentration of 2.5 ug/L (prepared solution use 10 mL/L)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
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