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Spermine, tetrahydrochloride

Spermine, tetrahydrochloride

$60.80

Key features and details

Spermine is a naturally occuring polyamine essential for cell growth in both normal and neoplastic tissue.

SKU: 02100474-CF

Synonyms
N,N-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride; Geontine Tetrahydrochloride
CAS Number:
306-67-2
Molecular Formula:
C10H26N4 · 4HCl
Molecular Weight:
348.2
Beilstein Registry Number:
3911771
EC Number:
206-189-8
MDL Number:
MFCD00012914
Product Description

Spermine is a naturally occuring polyamine that occurs in all eukaryotes, but is rare in prokaryotes. It is essential for cell growth in both normal and neoplastic tissue. Spermine is formed through the addition of a aminopropyl group to spermidine by spermine synthase. Spermine is strongly basic in character, and in aqueous solution at physiological pH, all of its amino groups will be positively charged.

Application Notes

Used to precipitate DNA from low salt aqueous buffers. Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Isolation of DNA | Precipitation of DNA

Specifications
SKU 02100474-CF
Alternate Names N,N-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride; Geontine Tetrahydrochloride
Application Notes Used to precipitate DNA from low salt aqueous buffers. Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken.
Base Catalog Number 100474
Beilstein Registry Number 3911771
Biochemical Physiological Actions Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site.
CAS # 306-67-2
EC Number 206-189-8
Format Powder
Hazard Statements H315-H319
Melting Point 312-314 °C (Lit.)
Molecular Formula C10H26N4 · 4HCl
Molecular Weight 348.2
Personal Protective Equipment Dust Mask, Eyeshields, Gloves.
pH 6.6 (1M)
Purity ≥96%
RTECS Number EJ7230000
Safety Symbol GHS07
Solubility Soluble in water (100 mg/mL - clear, colorless solution).
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Documents

Certificate of Analysis (COA)