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Folic acid (Vitamin B9 and folate) is essential to numerous bodily functions. The human body needs folate to synthesize DNA, repair DNA, and methylate DNA as well as to act as a cofactor in certain biological reactions. It is especially important in aiding rapid cell division and growth, such as in infancy and pregnancy.
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Cofactors | Enzymes | Inhibitors and Substrates | Folic Acid Metabolism
|Alternate Names||Pteroylglutamic Acid; N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl] amino]benzoyl]-L-glutamic acid; N-[p-[[(2-amino-4-hydroxy-6-pteridinyl) methyl]amino] benzoyl] glutamic acid; N-(p-[(2-amino-4-hydroxypyrimido[4,5-b]pyrazin-6-yl) methylamino] benzoyl) glutamic acid; PGA; Liver Lactobacillus casei factor; Vitamin Bc; Vitamin M; Folsure; PteGlu|
|Application Notes||Folic acid (Vitamin B9 and folate) is essential to numerous bodily functions. The human body needs folate to synthesize DNA, repair DNA, and methylate DNA as well as to act as a cofactor in certain biological reactions. It is especially important in aiding rapid cell division and growth, such as in infancy and pregnancy.|
|Base Catalog Number||101725|
|Beilstein Registry Number||100781|
|Biochemical Physiological Actions||Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon’ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).|
|Extinction Coefficient||9.12, 25.1, 26.9 (0.1 M NaOH)(Lit.)|
|Melting Point||482° F (decomposes) (NTP, 1992)|
|Molecular Weight||441.404 g/mol|
|Personal Protective Equipment||Eyeshields, Gloves, Respirator filter|
|pH||A suspension of 1 g of folic acid in 10 ml of <a class="pubchem-internal-link CID-962" href="https://pubchem.ncbi.nlm.nih.gov/compound/water">water</a> has a pH of 4.0-4.8. Aq solutions prepared with <a class="pubchem-internal-link CID-516892" href="https://pubchem.ncbi.nlm.nih.gov/compound/sodium%20bicarbonate">sodium bicarbonate</a> have a pH between 6.5 and 6.8.|
|Solubility||Almost insoluble (NTP, 1992)|
|UV Visible Absorbance||256 ± 3 nm (0.1 N NaOH)|
|Vapor Pressure||6.2X10-20 mm Hg at 25 deg C /Estimated/|