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Ebselen, 20 mg
Ebselen is a novel selenium-containing anti-flammatory agent.
Ebselen inhibits 5-LO, CO, NADPH oxidase, and protein kinase C. It is a potent antioxidant. It possesses a unique glutathione peroxidase-like activity. It is also shown to be an inhibitor of free radical induced apoptosis and neuroprotective agent.
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|Application Notes||Ebselen inhibits 5-LO, CO, NADPH oxidase, and protein kinase C. It is a potent antioxidant. It possesses a unique glutathione peroxidase-like activity. It is also shown to be an inhibitor of free radical induced apoptosis and neuroprotective agent.|
|Base Catalog Number||15880920|
|Biochemical Physiological Actions||Ebselen inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase by covalently modifying a cysteine residue, the effect being reversible with dithiothreitol. Inhibits oxidation of low density lipoproteins (LDL).|
|Melting Point||180 - 181 °C (Lit.)|
|Pack Size||20 mg|
|Safety Symbol||GHS06, GHS08, GHS09|
|Solubility||Soluble in DMSO (25 mg/mL) and ethanol (10 mg/mL). Also soluble in chloroform (19.60 - 20.40 mg/mL - clear yellow solution).|