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Dihydrostreptomycin sulfate is an antibiotic used in aminoglycoside uptake studies. It has also been used as an electrode for a cochlear amplifier in the hair-cell bundle of lizards.
|Alternate Names||Dihydrostreptomycin sesquisulfate; Dihydrostreptomycin|
|Application Notes||Dihydrostreptomycin sulfate is an antibiotic used in aminoglycoside uptake studies. It has also been used as an electrode for a cochlear amplifier in the hair-cell bundle of lizards.|
|Base Catalog Number||100405|
|Beilstein Registry Number||3894221|
|Biochemical Physiological Actions||Mode of action: Inhibits bacterial protein synthesis at the level of the 30S ribosomal subunit and the 16S rRNA.|
|Molecular Weight||1461.408 g/mol|
|Personal Protective Equipment||Eyeshields, Gloves, Respirator filter|
|Preparation Method||Add the appropriate amount of powder to water while mixing (not the reverse), as adding water to the powders may result in insoluble mixtures that cannot be filtered without losing potency. If desired, the pH may be adjusted, but a basal media with greater than 2 g/L sodium bicarbonate can easily absorb up to 2% of an acidic antibiotic solution; therefore, an antibiotic solution with an acidic pH would not influence the pH of the media. After ensuring that the resultant solution is transparent, sterile filter and store in small aliquots at appropriate temperature until use. Prior to use of the media, aseptically add the appropriate amount of antibiotic to the basal media in order to obtain the required working concentration. Mix well and sterile filter if asepsis is believed to have been compromised.|
|Typical Working Concentration||100 mg/L against Gram Negative Bacteria|