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Clotrimazole, 1 g

Clotrimazole, 1 g

Synonyms 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole; 1-(o-Chloro-α,α-diphenylbenzyl)imidazole; diphenyl-(2-chlorophenyl)-1-imidazolylmethane

CAS Number: 23593-75-1 Molecular Formula: C22H17ClN2 Molecular Weight: 344.8

EC Number: 245-764-8 MDL Number: MFCD00057220

Packaging size: 1 g

SKU 0219894401
$37.35
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Description

Product Description

Clotrimazole is a specific inhibitor of Ca2+-activated K+ channels. Clotrimazole is an imidazole derivative and antifungal compound which has similar antimicrobial action and activity to ketoconazole.

Application Notes

Clotrimazole is used as an antifungal azole. Clotrimazole has been utilized in vitro on cultured human prostate cancer cells to counteract the proliferative effects of 1-ethyl-2-benzimidazolinone and riluzole.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antifungal azole

Specifications
SKU 0219894401
Alternate Names 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole; 1-(o-Chloro-α,α-diphenylbenzyl)imidazole; diphenyl-(2-chlorophenyl)-1-imidazolylmethane
Application Notes Clotrimazole is used as an antifungal azole. Clotrimazole has been utilized in vitro on cultured human prostate cancer cells to counteract the proliferative effects of 1-ethyl-2-benzimidazolinone and riluzole.
Base Catalog Number 19894401
Biochemical Physiological Actions Mode of action: Inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.
CAS # 23593-75-1
EC Number 245-764-8
Hazard Statements H302-H315-H319
Melting Point 147 - 149 °C (Lit.)
Molecular Formula C22H17ClN2
Molecular Weight 344.8
Pack Size 1 g
Personal Protective Equipment Dust mask, Eyeshields, Gloves
RTECS Number NI4377000
Safety Symbol GHS07
Solubility Soluble in acetone, chloroform (50 mg/mL), ethyl acetate, DMF, DMSO (25 mM); slightly soluble in water, benzene, toluene.
Typical Working Concentration A concentration of 3μg/mL of clotrimazole is generally effective for inhibiting many fungal species that are sensitive to clotrimazole.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance λmax: 261 nm (Lit.)