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Clotrimazole, 1 g
Clotrimazole is a specific inhibitor of Ca2+-activated K+ channels. Clotrimazole is an imidazole derivative and antifungal compound which has similar antimicrobial action and activity to ketoconazole.
Clotrimazole is used as an antifungal azole. Clotrimazole has been utilized in vitro on cultured human prostate cancer cells to counteract the proliferative effects of 1-ethyl-2-benzimidazolinone and riluzole.
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|Alternate Names||1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole; 1-(o-Chloro-α,α-diphenylbenzyl)imidazole; diphenyl-(2-chlorophenyl)-1-imidazolylmethane|
|Application Notes||Clotrimazole is used as an antifungal azole. Clotrimazole has been utilized in vitro on cultured human prostate cancer cells to counteract the proliferative effects of 1-ethyl-2-benzimidazolinone and riluzole.|
|Base Catalog Number||19894401|
|Biochemical Physiological Actions||Mode of action: Inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.|
|Melting Point||147 - 149 °C (Lit.)|
|Pack Size||1 g|
|Personal Protective Equipment||Dust mask, Eyeshields, Gloves|
|Solubility||Soluble in acetone, chloroform (50 mg/mL), ethyl acetate, DMF, DMSO (25 mM); slightly soluble in water, benzene, toluene.|
|Typical Working Concentration||A concentration of 3μg/mL of clotrimazole is generally effective for inhibiting many fungal species that are sensitive to clotrimazole.|
|UV Visible Absorbance||λmax: 261 nm (Lit.)|