Inosine is the deaminated form of adenosine. It is a nucleoside consisting of hypoxathine and ribose. Its phosphate ester is inosinic acid. Inosine easily permeates the cell membrane and, taking part in glycolysis and the TCA cycle via the pentose phosphate pathway, elevates the intracellular level of ATP and stimulates biosynthesis of nucleic acids. Adaptation of these metabolic processes activates the cell, and the nucleoside is applicable to various disorders. Inosine accumulates in tissue during periods of ischemia and has been shown to degranulate mast cells in the hamster cheek pouch via activation of an A3 receptor.
Suppresses the increase of glucose and insulin in the blood. Inhibits cytokine production by a posttranscriptional mechanism.
|Alternate Names||9-β-D-Ribofuranosylhypoxathine; Hypoxanthine riboside; Hypoxanthosine|
|Application Notes||Suppresses the increase of glucose and insulin in the blood. Inhibits cytokine production by a posttranscriptional mechanism.|
|Base Catalog Number||10204980|
|Beilstein Registry Number||624896|
|Biochemical Physiological Actions||Inosine is a potent stimulator of nerve growth factor (NGF) induced neurite outgrowth. The elevated levels of inosine in brain following injury are associated with the increased expression proteins related to axonal regeneration and growth. Mice given inosine demonstrated enhanced recovery of fine motor control following ischemic brain damage. Inosine may be used in studies of the process A-to-I RNA editing.|
|Melting Point||212-213 °C(dec)|
|Pack Size||100 g|
|Personal Protective Equipment||Eyeshields, Gloves, respirator filter|
|Solubility||Soluble in 1 N HCl (30 mg/mL - clear, colorless solution), 50% ammonium hydroxide (10 mg/mL - clear, colorless solution); Slightly soluble in water (1.6 g/100 mL at 20°C); very slightly soluble in ethanol or chloroform; practically insoluble in ether.|
|UV Visible Absorbance||UV/Vis: λ max (water): 248 ± 3nm; OD250/OD260: 1.49 - 1.81; OD280/OD260: 0.21 - 0.31; OD290/OD260: 0.01 - 0.05|