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Uricase, or urate oxidase, is a copper-containing enzyme catalyzing specifically the oxidation of uric acid. It catalyzes the reaction of uric acid in accordance with the following reaction: Uric Acid + 2H2O + O2 ---------> Allantoin + CO2 + H2O2. Uricase is found in the kidneys, livers and spleens of almost all mammals, except in human beings and anthropoidea. It is also known that uricase exists in various kinds of bacteria.
Uricase is used for the determination of uric acid in clinical analysis.
Determination of uric acid in clinical analysis
|Alternate Names||Urate oxidase; Urate: oxygen oxoreductase; Uricase from <i>Candida sp.</i>|
|Application Notes||Uricase is used for the determination of uric acid in clinical analysis.|
|Base Catalog Number||10120325|
|Pack Size||25 U|
|pH||Optimum pH: Activation maximum at pH 8.5. Activity is scarecely observed at pH below 5.0 or over 11.0. Stable within the pH range of 7.0 to 11.0 (Lit.)|
|Specific Activity||≥3.0 u/mg solid|
|Unit Definition||1 unit oxidizes 1 umole of uric acid/min. at pH 8.5, 25 °C.|