Induces neuritogenesis. Potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex). Blocks proteasome activity by targeting the catalytic β-subunit. Apoptosis inducer. Anticancer compound. Upregulates HSP70 and HSP22. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Inhibits NF-κB activation by inhibiting IκB degradation. Cathepsin A inhibitor. β-Secretase activity inhibitor. Anti-adipogenic. Autophagy inducer.
Ubiquitination-Proteasome, Apoptosis, Cancer, Cell Biology, Enzyme Inhibitor, Autophagy
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|Application Notes||Ubiquitination-Proteasome, Apoptosis, Cancer, Cell Biology, Enzyme Inhibitor, Autophagy|
|Base Catalog Number||19586382|
|Pack Size||200 UG|
|Solubility||Soluble in water, methanol, ethanol, DMSO, pyridine, acetonitrile or dimethyl formamide. Insoluble in hexane, benzene, chloroform or ethyl acetate.|