Induces neuritogenesis. Potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex). Blocks proteasome activity by targeting the catalytic β-subunit. Apoptosis inducer. Anticancer compound. Upregulates HSP70 and HSP22. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Inhibits NF-κB activation by inhibiting IκB degradation. Cathepsin A inhibitor. β-Secretase activity inhibitor. Anti-adipogenic. Autophagy inducer.

Application Notes

Ubiquitination-Proteasome, Apoptosis, Cancer, Cell Biology, Enzyme Inhibitor, Autophagy

Usage Statement

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