Citric acid is a key metabolic intermediate. Citrate is the starting point of the tricarboxylic acid cycle. Its concentration also coordinates several other metabolic pathways. Citric acid can form complexes with various cations, particularly with iron and calcium. In animals, citric acid improves the utilization of nutritional calcium. Citric acid is produced commercially by fermentation of carbohydrates derived from corn starch and from beet molasses.
Citric Acid, Trisodium Salt, Dihydrate is used as a substrate for citrate lyase, a buffer component; an anticoagulant. For anticoagulation use it is typically used at a concentration of approximately 0.129 M (i.e. for 4.5 mL blood use 16.0 mg sodium citrate and 2.1 mg citric acid).
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Preparation of sodium citrate buffer for antigen unmasking in IHC
|Alternate Names||Citric Acid Trisodium Salt Dihydrate; Trisodium citrate dihydrate; Citronensaeure-tri-na-salz-dihydrat; Natriumcitrat-Dihydrat; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, dihydrate; Sodium citrate tribasic dihydrate; Sodium Citrate, trisodium salt|
|Application Notes||Citric Acid, Trisodium Salt, Dihydrate is used as a substrate for citrate lyase, a buffer component; an anticoagulant. For anticoagulation use it is typically used at a concentration of approximately 0.129 M (i.e. for 4.5 mL blood use 16.0 mg sodium citrate and 2.1 mg citric acid).|
|Base Catalog Number||19486880|
|Beilstein Registry Number||6104939|
|Boiling Point||309.6 °C at 760 mmHg (Lit.)|
|Density||1.76 g/cm3 (Lit.)|
|Melting Point||> 300 °C(Lit.)|
|Pack Size||100 g|
|Personal Protective Equipment||Eyeshields, Gloves, Respirator filter|
|pH||7.0 - 9.0 (5% aq soln)|
|Solubility||Freely soluble in water (> 100 mg/mL - clear, colorless solution). pH of a 0.1 M solution in water is approximately 7.5 to 9.0; Insoluble in alcohol.|