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Adenosine is a nucleotide resulting from the union of one molecule of sugar -- d-ribose -- with a base -- l-adenine. Adenosine is active in cardiovascular disorders. It is indicated in cases of angina pectoris on account of its property of increasing the coronary output and in cases of hypertension on account of its vasodilator action. It is also active on the peripheral circulation, dilating the capillary vessels.
It has also been recommended in the treatment of agranulocytosis for the same reason as adenine.
|Alternate Names||9-β-D-Ribofuranosyladenine; Adenine riboside; Adenine-9-β-D-ribofuranoside; Adenine riboside|
|Application Notes||It has also been recommended in the treatment of agranulocytosis for the same reason as adenine.|
|Base Catalog Number||19460925|
|Beilstein Registry Number||93029|
|Biochemical Physiological Actions||Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A<sub>1</sub> adenosine receptors. The antiplatelet and anti-inflammatory actions of adenosine appear to be mediated via the A<sub>2</sub> adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).|
|Extinction Coefficient||15.4 (259 nm, 0.01 M PO<sub>4</sub>, pH 7)|
|Grade||Cell Culture Grade|
|Optical Rotation||-61.7° (7 mg/100ml, in water) (lit.)|
|Pack Size||25 g|
|Personal Protective Equipment||Eyeshields, Gloves, respirator filter|
|pKa||3.5, 12.5 (lit.)|
|Solubility||Fairly soluble in cold water, soluble in room temperature water, freely soluble in hot water; soluble in 1 N hydrochloric acid (50 mg/ml - clear and colorless); insoluble in alcohol. Soluble in 1 M NH<sub>4</sub>OH (50 mg/ml), with heat as needed.|
|UV Visible Absorbance||λ max (1N HCl) 255-260 nm<br>OD250/OD260 0.80 - 0.90<br>OD280/OD260|