Dexamethasone 21-acetate is an anti-inflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils but to inhibit apoptosis in neutrophils.
Dexamethasone 21-acetate is a glucocorticoid anti-inflammatory agent.
|Alternate Names||9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate; 9α-Fluoro-16α-methylprednisolone-21-acetate; Prednisolone F acetate|
|Application Notes||Dexamethasone 21-acetate is a glucocorticoid anti-inflammatory agent.|
|Base Catalog Number||190041|
|Beilstein Registry Number||2342608|
|Biochemical Physiological Actions||An anti-inflammatory glucocorticoid.|
|Melting Point||232 - 233.5 °C(lit.)|
|Pack Size||500 mg|
|Solubility||Soluble in acetone (100mg/mL - Clear, Colorless to Light Yellow Solution).|