Dacarbazine , 250 mg

Specifications

SKU	0215751983
Alternate Names	5-[3,3-Dimethyl-1-triazenyl]imidazole-4-carboxamide; DTIC
Application Notes	Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents. It is used to induce apoptosis in human cells. It has been used to induce hepatotoxicity in mice.
Base Catalog Number	15751983
Biochemical Physiological Actions	Dacarbazine has significant activity against melanomas. It is a synthetic analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). Dacarbazine appears to exert cytotoxic effects by acting as an alkylating agent, by inhibiting DNA synthesis as a purine analog, and by inducing apoptosis. Dacarbazine is not cell cycle-phase specific.
CAS #	4342-03-4
EC Number	224-396-1
Hazard Statements	H312-H315-H319-H332-H335-H350
Melting Point	202 °C (Lit.)
Molecular Formula	C₆H₁₀N₆O
Molecular Weight	182.2
Pack Size	250 mg
Personal Protective Equipment	Eyeshields, full-face particle respirator, Gloves, respirator filter, respirator cartridges
RTECS Number	NI3950000
Safety Symbol	GHS07, GHS08
Solubility	Soluble in 1 M HCl (40 mg/mL - clear to turbid, faint yellow solution).
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

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