Happy Thanksgiving! Get a $50 Giftcard on us when you spend $400 or more, use promo code at the checkout: THANKYOU50. Offer ends Nov. 30th, 2020.


Tolnaftate, 1 g

Tolnaftate, 1 g


SKU: 0215693401

Methyl-[3-methylphenyl]-carbamothioic acid O-2-naphthyl ester; Carbamothioic acid
CAS Number:
Molecular Formula:
Molecular Weight:
EC Number:
MDL Number:
Packaging size:
1 g
SKU 0215693401
Alternate Names Methyl-[3-methylphenyl]-carbamothioic acid O-2-naphthyl ester; Carbamothioic acid
Application Notes Tolfanate is an antifungal compound which has activity against such species as Epidermophyton, Microsporum, Trichophyton species, and Malassezia furfur. It is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies.
Base Catalog Number 15693401
Biochemical Physiological Actions Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. Tolnaftate inhibits biosynthesis of aflatoxin.
CAS # 2398-96-1
EC Number 219-266-6
Extinction Coefficient E1% = 690 -740 at λ max 257 - 258 NM in methanol (Lit.)
Melting Point 108 - 115 °C
Molecular Formula C19H17NOS
Molecular Weight 307.42
Pack Size 1 g
Personal Protective Equipment Eyeshields, Gloves, respirator filter
RTECS Number FD8891300
Solubility Soluble in chloroform (50 mg/mL - clear, colorless to faint yellow solution). Insoluble in cold and hot water. It is also soluble in acetone and sparingly soluble in ethanol and methanol.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.