Ribostamycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.
It is used in pharmacokinetic and nephrotoxicity studies.
|Alternate Names||Landamycine; Ribomycine; Ribostamin; Ribostamycin Sulfate; SF 733 Antibiotic Sulfate; Vistamycin|
|Application Notes||It is used in pharmacokinetic and nephrotoxicity studies.|
|Base Catalog Number||15654380|
|Biochemical Physiological Actions||Aminoglycosides, such as ribostamycin, bind to the bacterial 30S and 50S ribosomal subunit, which inhibits the translocation of the peptidyl-tRNA from the A-site to the P-site. This causes misreading of mRNA which makes bacteria unable to make essential proteins. It also inhibits the chaperone activity of protein disulfide isomerase (PDI).|
|Pack Size||100 mg|
|Personal Protective Equipment||Eyeshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter|
|Safety Symbol||GHS07, GHS08|
|Solubility||Soluble in water (200 mg/4 mL-clear, colorless solution).|