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Kanamycin monosulfate, USP grade

Kanamycin monosulfate, USP grade

$47.50

Key features and details

Kanamycin Monosulfate

SKU: 02199853-CF

Synonyms
Kanamycin A; Kanamycin sulfate salt
CAS Number:
25389-94-0
Molecular Formula:
C18H36N4O11 • H2SO4
Molecular Weight:
582.575 g/mol
EC Number:
246-933-9
MDL Number:
MFCD00070253
Product Description

Kanamycin Monosulfate

Application Notes

Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibiotic | Inhibitor of protein synthesis

Specifications
SKU 02199853-CF
Alternate Names Kanamycin A; Kanamycin sulfate salt
Application Notes Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene.
Base Catalog Number 199853
Biochemical Physiological Actions Kanamycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Specifically Kanamycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
CAS # 25389-94-0
EC Number 246-933-9
Grade USP
Hazard Statements H360
Molecular Formula C18H36N4O11 • H2SO4
Molecular Weight 582.575 g/mol
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Potency >750 µg/mg
RTECS Number NZ3225030
Safety Symbol GHS08
Source Streptomyces kanamycetikus
Typical Working Concentration cell culture applications at 100 mg/mL.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Citations
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