5-Fluorocytosine is used in studies on TMP biosynthesis. It is used as an antifungal agent. It has also been used as a selection agent for plastids in transgenic plants.
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Used in studies on TMP biosynthesis | Antifungal
|Alternate Names||4-Amino-5-fluoro-2-hydroxypyrimidine; Flucystine; 4-amino-5-fluoro-2(1H)-pyrimidinone; Flucytosine|
|Application Notes||5-Fluorocytosine is used in studies on TMP biosynthesis. It is used as an antifungal agent. It has also been used as a selection agent for plastids in transgenic plants.|
|Base Catalog Number||199792|
|Beilstein Registry Number||127285|
|Biochemical Physiological Actions||5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. 5-Fluorocytosine inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis.|
|Extinction Coefficient||EmM= 8.91 (in 0.1 M HCl) (Lit.)|
|Melting Point||296 Â°C|
|Molecular Weight||129.094 g/mol|
|Personal Protective Equipment||Eyeshields, Gloves, respirator filter|
|UV Visible Absorbance||λ max (0.1 N HCl) 284 - 286 nm|