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(-)-Epigallocatechin gallate

Product Description

(-)-Epigallocatechin Gallate

Application Notes

(-)-Epigallocatechin Gallate inhibits cellular oxidation of low density lipoproteins. It also inhibits the peroxynitrite-induced formation of the oxidative injury markers 8-hydroxy-2-deoxy guanosine and 3-nitrotyrosine, apoptosis in human prostate cancer cells. Selectively inhibits activation of JNK/SAPK signaling pathway and suppresses proliferation of vascular smooth muscle cells. Shows growth inhibitory effects on tumor cells but not their normal counterparts. Inhibits telomerase. A fast-binding and reversible fatty acid synthase inhibitor. Inhibits PMA-induced skin thickening. Inhibits activation of interleukin-1α mRNA and protein expression. Inhibits nitric oxide synthase (iNOS) gene expression. At µM concentrations, it inhibits VEGF-induced tyrosine phosphorylation.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Inhibits cellular oxidation

Specifications

SKU	02199165-CF
Alternate Names	(2R,3R)-2-(3,4,5-Trihydroxyphenyl)- 3,4-dihydro- 1(2H)- benzopyran-3,5,7- triol 3-(3,4,5-trihydroxybenzoate); (-)-Epigallocatechin 3-O-gallate; EGCG; (−)-cis-3,3′,4′,5,5′,7-Hexahydroxy-flavane-3-gallate; (−)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate
Application Notes	(-)-Epigallocatechin Gallate inhibits cellular oxidation of low density lipoproteins. It also inhibits the peroxynitrite-induced formation of the oxidative injury markers 8-hydroxy-2-deoxy guanosine and 3-nitrotyrosine, apoptosis in human prostate cancer cells. Selectively inhibits activation of JNK/SAPK signaling pathway and suppresses proliferation of vascular smooth muscle cells. Shows growth inhibitory effects on tumor cells but not their normal counterparts. Inhibits telomerase. A fast-binding and reversible fatty acid synthase inhibitor. Inhibits PMA-induced skin thickening. Inhibits activation of interleukin-1α mRNA and protein expression. Inhibits nitric oxide synthase (iNOS) gene expression. At µM concentrations, it inhibits VEGF-induced tyrosine phosphorylation.
Base Catalog Number	199165
Biochemical Physiological Actions	Antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
CAS #	989-51-5
Extinction Coefficient	EM(275 nm) = 11,500 (ethanol)(Lit.)
Format	Powder
Melting Point	140 - 142 °C
Molecular Formula	C22H18O11
Molecular Weight	458.375 g/mol
Optical Rotation	-185° ±2° (ethanol)(Lit.)
Personal Protective Equipment	Eyeshields, Gloves, Respirator filter
Purity	≥95%
RTECS Number	KB5200000
Source	Green tea; Folium Camelliae
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.