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(±)-Verapamil hydrochloride

$80.60

Key features and details

(±)-Verapamil Hydrochloride

SKU: 02195545-CF

Synonyms

Isoptin; 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-Dimethoxyphenyl)-2-isopropylvaleronitrile; Iproveratril; 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl) benzeneacetonitrile; α-isopropyl-α-[(N-methyl-N-homoveratryl)-?-aminopropyl]-3,4-dimethoxyphenylacetonitrile

CAS Number:

152-11-4

Molecular Formula:

C27H38N2O4·HCl

Beilstein Registry Number:

3647093

EC Number:

205-800-5

MDL Number:

MFCD00055208

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Product Description

(±)-Verapamil Hydrochloride

Application Notes

(±)-Verapamil hydrochloride is a calcium channel (L-type) modulator, adrenoceptor antagonist, anti-arrhythmic, cardiac depressant, and coronary vasodilator. It is also a calcium channel-blocker. It acts by inhibiting the slow channel entry of calcium into the cell. It acts by plugging up the channels and limiting the entry of calcium into both smooth muscle cells of arteriolar walls and the ardiac muscle cells at higher doses.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Coronary vasodilator

Specifications

SKU	02195545-CF
Alternate Names	Isoptin; 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-Dimethoxyphenyl)-2-isopropylvaleronitrile; Iproveratril; 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl) benzeneacetonitrile; α-isopropyl-α-[(N-methyl-N-homoveratryl)-?-aminopropyl]-3,4-dimethoxyphenylacetonitrile
Application Notes	(±)-Verapamil hydrochloride is a calcium channel (L-type) modulator, adrenoceptor antagonist, anti-arrhythmic, cardiac depressant, and coronary vasodilator. It is also a calcium channel-blocker. It acts by inhibiting the slow channel entry of calcium into the cell. It acts by plugging up the channels and limiting the entry of calcium into both smooth muscle cells of arteriolar walls and the ardiac muscle cells at higher doses.
Base Catalog Number	195545
Beilstein Registry Number	3647093
Biochemical Physiological Actions	Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.
CAS #	152-11-4
EC Number	205-800-5
Extinction Coefficient	EmM = 16.1 (232 nm in ethanol); 6.1 (280 nm in ethanol)(Lit.)
Format	Powder
Hazard Statements	H301-H311-H331
Molecular Formula	C27H38N2O4·HCl
Personal Protective Equipment	Eyeshields, Faceshields, Gloves, Respirator cartridge
pKa	8.6 (Lit.)
RTECS Number	YV8320000
Safety Symbol	GHS06
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.