Muscimol

Application Notes

Muscimol has been widely used to reversibly inactivate localized groups of neurons. It can also be used, in place of radioactive reagents and methods, to map the distribution of muscimol in the nervous system, as well as to detect the presence of GABAA receptors on cell surfaces. Muscimol was also reported to cause change in the water intake of the mice. In cultured rat oligodendrocytes, muscimol has been shown to lead to a reduction in intracellular Cl-content, cell shrinkage, and stimulated Na-K-2Cl cotransporter isoform 1 (NKCC1) activity. Muscimol (50 mM) has been utilized to probe the role of the p42/44 mitogenactivated protein kinase (MAPK) cascade in the development of cultured rat hypothalamic neurons.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

GABA-agonist

SKU	02195336-CF
Alternate Names	3-Hydroxy-5-aminomethylisoxazole; 5-Aminomethyl-3-hydroxy-isoxazole; 5-Aminomethyl-3-isoxazolol
Application Notes	Muscimol has been widely used to reversibly inactivate localized groups of neurons. It can also be used, in place of radioactive reagents and methods, to map the distribution of muscimol in the nervous system, as well as to detect the presence of GABAA receptors on cell surfaces. Muscimol was also reported to cause change in the water intake of the mice. In cultured rat oligodendrocytes, muscimol has been shown to lead to a reduction in intracellular Cl-content, cell shrinkage, and stimulated Na-K-2Cl cotransporter isoform 1 (NKCC1) activity. Muscimol (50 mM) has been utilized to probe the role of the p42/44 mitogenactivated protein kinase (MAPK) cascade in the development of cultured rat hypothalamic neurons.
Base Catalog Number	195336
Beilstein Registry Number	1618960
Biochemical Physiological Actions	GABAA receptor agonist.
CAS #	2763-96-4
EC Number	220-430-4
Format	Powder
Hazard Statements	H300
Melting Point	347° F decomposes (EPA, 1998)
Molecular Formula	C4H6N2O2
Molecular Weight	114.104 g/mol
Personal Protective Equipment	Eyeshields, Faceshields, Gloves, Respirator cartridges
RTECS Number	NY3325000
Safety Symbol	GHS06
Solubility	In <a class="pubchem-internal-link CID-962" href="https://pubchem.ncbi.nlm.nih.gov/compound/water">water</a>, 5.67X10+5 mg/L (est)
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure	2.94X10-4 mm Hg at 25 deg C (est)