Miconazole

Application Notes

Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion. It is used to inhibit cytochrome P450 and to study automated luminescence-based cytochrome P450 profiling

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Anti-fungal agent

SKU	02193915-CF
Alternate Names	1-[2,4-Dichloro-β-([2,4-dichlorobenzyl]oxy)phenethyl]imidazole; 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole; Monistat; Daktarin IV; Miconazolo; Miconazolum; Dactarin; Miconazol; Minostate; Brentan; Florid(nitrate)
Application Notes	Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion. It is used to inhibit cytochrome P450 and to study automated luminescence-based cytochrome P450 profiling
Base Catalog Number	193915
Biochemical Physiological Actions	Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.
CAS #	22916-47-8
EC Number	245-324-5
Format	Powder
Melting Point	159-163 °C
Molecular Formula	C18H14Cl4N2O
Molecular Weight	416.123 g/mol
RTECS Number	NI4770000
Solubility	Water Solubility1g/100mL (20 °C)
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.