Furazolidone

Application Notes

Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes. It also used as a DNA interstrand cross-linking agent.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibacterial

SKU	02193465-CF
Alternate Names	3-[[(5-Nitro-2-furanyl)methylene]-amino]-2-oxazolidinone; 3-(5-nitrofurfurylideneamino)-2-oxazolidinone; N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone; Furovag; Furoxane; Medaron; Topazone
Application Notes	Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes. It also used as a DNA interstrand cross-linking agent.
Base Catalog Number	193465
Beilstein Registry Number	8317414
Biochemical Physiological Actions	Furazolidone and its generated free radicals, may bind to DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug, which results in high levels of mutations (transitions and transversions) in the bacterial chromosome. Its mechanism of action minimizes the development of resistant organisms. Furazolidone is a monoamine oxidase (MAO) inhibitor. It increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes.
CAS #	67-45-8
EC Number	200-653-3
Format	Powder
Hazard Statements	H361
Melting Point	254-256
Molecular Formula	C8H7N3O5
Molecular Weight	225.16 g/mol
Personal Protective Equipment	Eyeshields, full-face particle respirator, Gloves, respirator filter,respirator cartridges
RTECS Number	RQ3675000
Safety Symbol	GHS08
Solubility	Water Solubility40 mg/L (at 25 °C)
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.