Naloxone Hydrochloride

Application Notes

The role of naloxone (1 µM) and other opioids on apoptosis in several human cancer cell lines has been probed. Naloxone (10-100 µM) has been used to study proliferation and neurogenesis in cultured rat adult hippocampal progenitors. Naloxone has also been utilized to modulate the NMDA receptor activation capability of the µ-opioid receptor agonist DAMGO.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Opiate antagonist

SKU	02190245-CF
Alternate Names	Narcan; EN-1530; (5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride; 17-allyl-4,5α- epoxy-3,14-dihydroxymorphinan-6-one hydrochloride; (-)-N-allyl-14- hydroxynordihydromorphinone; N-allylnoroxymorphone;
Application Notes	The role of naloxone (1 µM) and other opioids on apoptosis in several human cancer cell lines has been probed. Naloxone (10-100 µM) has been used to study proliferation and neurogenesis in cultured rat adult hippocampal progenitors. Naloxone has also been utilized to modulate the NMDA receptor activation capability of the µ-opioid receptor agonist DAMGO.
Base Catalog Number	190245
Beilstein Registry Number	6260807
Biochemical Physiological Actions	Naloxone has an extremely high affinity for μ-opioid receptors in the central nervous system. Naloxone is a μ-opioid receptor competitive antagonist, and its rapid blockade of those receptors often produces rapid onset of withdrawal symptoms. Naloxone also has an antagonist action, though with a lower affinity, at κ- and δ-opioid receptors.
CAS #	357-08-4
EC Number	206-611-0
Format	Crystalline powder
Hazard Statements	H315-H319-H335
Molecular Formula	C19H21NO4 • HCl
Personal Protective Equipment	Dust mask, Eyeshields, Gloves
RTECS Number	QD2275000
Safety Symbol	GHS07
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.