Anisomycin

Application Notes

Anisomycin is an antiprotozoal agent. It inhibits protein synthesis. Activates a restricted subset of kinases currently only identified by p54 and MAP kinase. Study aid for cytoplasmic signals resulting in nuclear signaling and induction of c-fos and c-jun.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Inhibits protein synthesis | Activates a restricted subset of kinases | Study aid for cytoplasmic signals resulting in nuclear signaling and induction of c-fos and c-jun.

SKU	02159881-CF
Alternate Names	2-[p-Methoxybenzyl]-3,4- pyrrolidinediol 3-acetate; (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate; Flagecidin
Application Notes	Anisomycin is an antiprotozoal agent. It inhibits protein synthesis. Activates a restricted subset of kinases currently only identified by p54 and MAP kinase. Study aid for cytoplasmic signals resulting in nuclear signaling and induction of c-fos and c-jun.
Base Catalog Number	159881
Beilstein Registry Number	20705
Biochemical Physiological Actions	Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK).
CAS #	22862-76-6
EC Number	245-269-7
Format	Powder
Hazard Statements	H301
Molecular Formula	C14H19NO4
Molecular Weight	265.309 g/mol
Optical Rotation	[α]D23 = −30 ° (methanol) (Lit.)
Personal Protective Equipment	Eyeshields, Faceshields, Gloves, respirator cartridges
Purity	≥97%
RTECS Number	BZ9800000
Safety Symbol	GHS06
Source	Streptomyces griseolus
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.