Rosmarinic Acid

Application Notes

Rosmarinic Acid has been shown to dose dependently inhibit migration, adhesion, and invasion of Ls174-T human colon carcinoma cells. Rosmarinic Acid has been documented to increase the melanin content in B16 melanoma cells through activation of protein kinase A. In the same study rosmarinic acid induced the phosphorylation of CRE-binding protein (CREB) and activated cAMP response element (CRE). In the classical complement pathway Rosmarinic Acid inhibited C3-convertase. It also has shown to be a activator of GPR35.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

SKU	02159792-CF
Alternate Names	(R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid; 3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester
Application Notes	Rosmarinic Acid has been shown to dose dependently inhibit migration, adhesion, and invasion of Ls174-T human colon carcinoma cells. Rosmarinic Acid has been documented to increase the melanin content in B16 melanoma cells through activation of protein kinase A. In the same study rosmarinic acid induced the phosphorylation of CRE-binding protein (CREB) and activated cAMP response element (CRE). In the classical complement pathway Rosmarinic Acid inhibited C3-convertase. It also has shown to be a activator of GPR35.
Base Catalog Number	159792
Beilstein Registry Number	2227587
Biochemical Physiological Actions	Rosmarinic acid has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive performance, Alzheimer′s disease prevention, kideney disease treatment, cardioprotection and cancer chemoprevention.
CAS #	20283-92-5
Density	1.547 g/cu cm
Format	Powder
Hazard Statements	H301-H400
Melting Point	171-175 deg C
Molecular Formula	C18H16O8
Molecular Weight	360.318 g/mol
RTECS Number	GD8990000
Safety Symbol	GHS06, GHS09
Solubility	Soluble in <a class="pubchem-internal-link CID-702" href="https://pubchem.ncbi.nlm.nih.gov/compound/ethanol">ethanol</a>, <a class="pubchem-internal-link CID-679" href="https://pubchem.ncbi.nlm.nih.gov/compound/DMSO">DMSO</a> or <a class="pubchem-internal-link CID-6228" href="https://pubchem.ncbi.nlm.nih.gov/compound/dimethyl-formamide">dimethyl formamide</a> to approximately 25 mg/mL
Typical Working Concentration	inhibits lipid peroxidation of rat liver microsomes b 90% at a concentration of 25 µg/ml.
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure	1.1X10-13 mm Hg at 25 deg C (est)