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Thapsigargin may be used to distinguish between discrete intracellular Ca2+ pools. It induces apoptosis in rat thymocytes and in human hepatoma cells.
Apoptosis inducer | Calcium releaser
|Application Notes||Thapsigargin may be used to distinguish between discrete intracellular Ca2+ pools. It induces apoptosis in rat thymocytes and in human hepatoma cells.|
|Base Catalog Number||158999|
|Biochemical Physiological Actions||Potent, cell-permeable, IP3-independent intracellular calcium releaser. Blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. Induces apoptosis by disrupting intracellular free Ca2+ levels; incorporated into chemotherapeutic prodrug formulations.|
|Molecular Weight||650.762 g/mol|
|Personal Protective Equipment||Dust mask, Eyeshields, Faceshields, Gloves|
|Refractive Index||n20D 1.54 (Predicted)(Lit.)|
|Safety Symbol||GHS07, GHS08|