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5-Aza-2′-deoxycytidne

5-Aza-2′-deoxycytidne

$78.00

Key features and details

5-Aza-2′-Deoxycytidne

SKU: 02154803-CF

Synonyms
4-Amino-1-(2-deoxy-b-D-ribofuranosyl)-1,3,5-triazin-2 (1H)-one; 2' Deoxy-5-azaxytidine; 2-Deoxy-5-azacytidine; Decitabine
CAS Number:
2353-33-5
Molecular Formula:
C8H12N4O4
Molecular Weight:
228.208 g/mol
Beilstein Registry Number:
617982
EC Number:
219-089-4
MDL Number:
MFCD00043011
Product Description

5-Aza-2′-Deoxycytidne

Application Notes

5-Aza-2′-Deoxycytidine has been founf to induce changes in the differentiated state of cultured mouse embryo cells and additionally inhibits DNA methyltransferase (Dnmt). DNA methylation has been noted to be important in determining apoptotic susceptibility to histone deacetylase inhibitors, and its prevention can cause gene silencing and transcriptional repression. Other studies suggest that cell exposure to 5-Aza-2′-Deoxycytidine causes a change in replication timing, reactivation of repressed genes, and decondensation of heterochromatin. Furthermore, this agent demonstrates the ability to induce histone hyperacetylation in murine centromeric heterochromatin and also affect intranuclear distribution of histone deacetylase 2

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

DNA demethylation

Specifications
SKU 02154803-CF
Alternate Names 4-Amino-1-(2-deoxy-b-D-ribofuranosyl)-1,3,5-triazin-2 (1H)-one; 2' Deoxy-5-azaxytidine; 2-Deoxy-5-azacytidine; Decitabine
Application Notes 5-Aza-2′-Deoxycytidine has been founf to induce changes in the differentiated state of cultured mouse embryo cells and additionally inhibits DNA methyltransferase (Dnmt). DNA methylation has been noted to be important in determining apoptotic susceptibility to histone deacetylase inhibitors, and its prevention can cause gene silencing and transcriptional repression. Other studies suggest that cell exposure to 5-Aza-2′-Deoxycytidine causes a change in replication timing, reactivation of repressed genes, and decondensation of heterochromatin. Furthermore, this agent demonstrates the ability to induce histone hyperacetylation in murine centromeric heterochromatin and also affect intranuclear distribution of histone deacetylase 2
Base Catalog Number 154803
Beilstein Registry Number 617982
Biochemical Physiological Actions 5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
CAS # 2353-33-5
EC Number 219-089-4
Extinction Coefficient EmM= 8.2 (239 nm and pH 4.0)(Lit.)
Format Crystalline powder
Hazard Statements H302-H315-H319-H335-H341-H360
Molecular Formula C8H12N4O4
Molecular Weight 228.208 g/mol
Optical Rotation +74.0 ° to +80.0 ° (Lit.)
Personal Protective Equipment Dust mask, Eyeshields, Gloves
RTECS Number XZ3012000
Safety Symbol GHS07, GHS08
Solubility Water SolubilitySparingly soluble
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Documents

Certificate of Analysis

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Datasheet

Datasheet

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