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n-Propyl gallate is used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.
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|Alternate Names||Gallic Acid; Propyl Ester; Progallin P; n-Propyl Ester of 3,4,5-Trihydroxybenzoic Acid; Propyl gallate; n-Propyl-3,4,5-Trihydroxybenzoate; 3,4,5-Trihydroxybenzene-1-propylcarboxylate; 3.4.5-Tihydroxybenzoic acid n-propl ester|
|Application Notes||n-Propyl gallate is used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.|
|Base Catalog Number||102747|
|Beilstein Registry Number||1877976|
|Biochemical Physiological Actions||An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.|
|Boiling Point||Decomposes (NTP, 1992)|
|Density||1.21 (NTP, 1992)|
|Extinction Coefficient||EmM = 10.2 (272 nm, 1 M HCl) (Lit.)|
|Flash Point||368° F (NTP, 1992)|
|Melting Point||302° F (NTP, 1992)|
|Molecular Weight||212.201 g/mol|
|Personal Protective Equipment||Dust mask , Eyeshields, Faceshields, Gloves|
|pH||pH = 6.3 (0.05% aqueous solution); pH = 5.9 (0.1% aqueous solution); pH = 5.7 (0.2% aqueous solution)|
|Solubility||less than 1 mg/mL at 68° F (NTP, 1992)|
|Vapor Density||7.3 (NTP, 1992) (Relative to Air)|
|Vapor Pressure||2.6X10-7 mm Hg at 25 deg C (est)|