Hydroxyurea

Application Notes

Hydroxyurea induces apoptosis of in vitro myelogenous leukemia lymphocytes, and the phosphorylation of FADD and p53. It is also used to reduce the rate of painful attacks in sickle-cell disease and has antiretroviral properties in diseases such as AIDS.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Cancer Research | Apoptosis and Cell Cycle

SKU	02102023-CF
Alternate Names	Hydroxycarbamide; Carrbamoyl Oxime; N-(Aminocarbonyl) Hydroxyamine; Oxyurea
Application Notes	Hydroxyurea induces apoptosis of in vitro myelogenous leukemia lymphocytes, and the phosphorylation of FADD and p53. It is also used to reduce the rate of painful attacks in sickle-cell disease and has antiretroviral properties in diseases such as AIDS.
Base Catalog Number	102023
Beilstein Registry Number	1741548
Biochemical Physiological Actions	Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.
CAS #	127-07-1
EC Number	204-821-7
Format	Crystalline powder
Hazard Statements	H361
Molecular Formula	CH4N2O2
Personal Protective Equipment	Eyeshields, Full-face particle respirator, Gloves, Respirator cartridge, Respirator filter
RTECS Number	YT4900000
Safety Symbol	GHS08
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.