Cart
 
In Stock

L-Histidine, monohydrochloride, monohydrate

L-Histidine, monohydrochloride, monohydrate

$22.95

Key features and details

L-Histidine Monohydrochloride Monohydrate

SKU: 02101957-CF

Synonyms
L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride; (S)-α-amino-1H-imidazole-4-propanoic acid hydrochloride; glyoxaline-5-alanine hydrochloride;His;H
CAS Number:
5934-29-2
Molecular Formula:
C6H9N3O2 • HCl • H2O
Molecular Weight:
209.63 g/mol
Beilstein Registry Number:
4168261
MDL Number:
MFCD00151027
Product Description

L-Histidine Monohydrochloride Monohydrate

Application Notes

L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis. Exogenous histidine has been shown to enhance the biosynthesis of lovastatin by cultured Aspergillus terreus. Histidine has been utilized as a single nitrogen source to probe swarming in Pseudomonas aeruginosa on agar. An in vivo study has used L-histidine to diminish the net secretory response of the small intestine of of cholera toxin-challenged mice.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Specifications
SKU 02101957-CF
Alternate Names L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride; (S)-α-amino-1H-imidazole-4-propanoic acid hydrochloride; glyoxaline-5-alanine hydrochloride;His;H
Application Notes L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis. Exogenous histidine has been shown to enhance the biosynthesis of lovastatin by cultured Aspergillus terreus. Histidine has been utilized as a single nitrogen source to probe swarming in Pseudomonas aeruginosa on agar. An in vivo study has used L-histidine to diminish the net secretory response of the small intestine of of cholera toxin-challenged mice.
Base Catalog Number 101957
Beilstein Registry Number 4168261
Biochemical Physiological Actions Because the pKa of the imidazole group is close to physiological pH, the imidazole moiety can be either uncharged or positively charged, depending on the local environment. This property makes histidine residues of exceptional interest in the active sites of many proteins, such as hemoglobin and myoglobin, where the imidazole ring can readily alternate between the charged (imidazolium) and uncharged (imidazole) states to participate in bond formation and breakage. Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. In turn, histidine is degraded to glutamate by histidase, urocanase, and imidazolonepropionase via the formation of urocanate, 4-imidazolone 5-propionate, and N-formiminoglutamate.
CAS # 5934-29-2
Format Powder
Isoelectric Point 7.641(Lit.)
Molecular Formula C6H9N3O2 • HCl • H2O
Molecular Weight 209.63 g/mol
Optical Rotation +9.5° ± 1° (c = 1, 6NHCl)
Personal Protective Equipment Eyeshields, Gloves, respirator filter
pKa 1.80 (COOH), 9.33 (NH2), 6.04 (imidazole group)(Lit.)
RTECS Number MS3119000
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Documents

Certificate of Analysis

Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis

Datasheet

Datasheet

Material Safety Datasheet

Material Safety Datasheet
en_AE
Material Safety Datasheet
de_AT
Material Safety Datasheet
en_AU
Material Safety Datasheet
fr_BE
Material Safety Datasheet
nl_BE
Material Safety Datasheet
en_CA
Material Safety Datasheet
fr_CA
Material Safety Datasheet
de_CH
Material Safety Datasheet
fr_CH
Material Safety Datasheet
it_CH
Material Safety Datasheet
cn_ZH
Material Safety Datasheet
de_DE
Material Safety Datasheet
es_ES
Material Safety Datasheet
fi_FI
Material Safety Datasheet
fr_FR
Material Safety Datasheet
en_GB
Material Safety Datasheet
tw_ZH
Material Safety Datasheet
en_ID
Material Safety Datasheet
en_IE
Material Safety Datasheet
en_IN
Material Safety Datasheet
it_IT
Material Safety Datasheet
ja_JP
Material Safety Datasheet
de_LI
Material Safety Datasheet
de_LU
Material Safety Datasheet
en_MT
Material Safety Datasheet
es_MX
Material Safety Datasheet
no_NO
Material Safety Datasheet
pt_PT
Material Safety Datasheet
ru_RU
Material Safety Datasheet
sv_SE
Material Safety Datasheet
en_US