Polymyxin B Sulfate
Polymyxin B sulfate is a mixture of Polymyxin B1 and B2 sulfate. It is used clinically to treat infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. It is used to study multidrug-resistant pathogens.
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|Application Notes||Polymyxin B sulfate is a mixture of Polymyxin B1 and B2 sulfate. It is used clinically to treat infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. It is used to study multidrug-resistant pathogens.|
|Base Catalog Number||100565|
|Biochemical Physiological Actions||Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.|
|Molecular Weight||1301.571 g/mol|
|Personal Protective Equipment||Dust mask, Eyeshields, Gloves|
|Solubility||Water Solubility25 mg/mL|
|Source||Soluble in water; 1 mM HCl|
|Unit Definition||Effective concentration is typically 50 mg/L.|