Cytosine-Β-D-Arabinofuranoside Hydrochloride

Application Notes

It is used as an antineoplastic and antiviral agent.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Selective inhibitor of DNA synthesis

SKU	02100071-CF
Alternate Names	AraC; Arabinosylcytosine; 1-β-D-Arabinofuranosylcytosine; Cytabarine; Cytosine 1-(β-D-Arabinofuranosyl)cytosine hydrochloride; Ara-C hydrochloride; Arabinocytidine hydrochloride; Arabinosylcytosine hydrochloride; Cytarabine hydrochloride; Cytosine arabinoside hydrochloride; Cylocide; Cytosar Hydrochloride; Iretin; Spongocytidine Hydrochloride
Application Notes	It is used as an antineoplastic and antiviral agent.
Base Catalog Number	100071
Biochemical Physiological Actions	Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. Does not inhibit RNA synthesis. Anti-leukemia agent.
CAS #	69-74-9
EC Number	200-713-9
Format	Powder
Hazard Statements	H317-H319-H341-H361
Melting Point	356 to 360Â° F (NTP, 1992)
Molecular Formula	C9H13N3O5 • HCl
Molecular Weight	279.677 g/mol
RTECS Number	HA5500000
Safety Symbol	GHS07, GHS08
Solubility	>42 [ug/mL]
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance	λmax (water) 280 ± 6 nm
Vapor Pressure	8.74X10-12 mm Hg at 25 deg C (est)