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It is used as an antineoplastic and antiviral agent.
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Selective inhibitor of DNA synthesis
|Alternate Names||AraC; Arabinosylcytosine; 1-β-D-Arabinofuranosylcytosine; Cytabarine; Cytosine 1-(β-D-Arabinofuranosyl)cytosine hydrochloride; Ara-C hydrochloride; Arabinocytidine hydrochloride; Arabinosylcytosine hydrochloride; Cytarabine hydrochloride; Cytosine arabinoside hydrochloride; Cylocide; Cytosar Hydrochloride; Iretin; Spongocytidine Hydrochloride|
|Application Notes||It is used as an antineoplastic and antiviral agent.|
|Base Catalog Number||100071|
|Biochemical Physiological Actions||Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. Does not inhibit RNA synthesis. Anti-leukemia agent.|
|Melting Point||356 to 360Â° F (NTP, 1992)|
|Molecular Formula||C9H13N3O5 • HCl|
|Molecular Weight||279.677 g/mol|
|Safety Symbol||GHS07, GHS08|
|Usage Statement||Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.|
|UV Visible Absorbance||λmax (water) 280 ± 6 nm|
|Vapor Pressure||8.74X10-12 mm Hg at 25 deg C (est)|