β2-Microglobulin, 500 µg
β2-Microglobulin
Application Notes
To study the effect of β2 microglobulin , mice models deficient for the β2 microglobulin gene have been engineered. These mice demonstrate that β2 microglobulin is necessary for cell surface expression of MHC class I and stability of the peptide binding groove.In the absence of β2 microglobulin, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface whereas in the absence of MHC class I, CD8 T cells cannot develop. Low levels of β2 microglobulin can indicate non-progression of HIV.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Stability of the MHC antigens
| SKU | 02153903.5 |
| Alternate Names | β2-Microglobulin; β2-M |
| Application Notes | To study the effect of β2 microglobulin , mice models deficient for the β2 microglobulin gene have been engineered. These mice demonstrate that β2 microglobulin is necessary for cell surface expression of MHC class I and stability of the peptide binding groove.In the absence of β2 microglobulin, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface whereas in the absence of MHC class I, CD8 T cells cannot develop. Low levels of β2 microglobulin can indicate non-progression of HIV. |
| Base Catalog Number | 153903.5 |
| Biochemical Physiological Actions | A transient complex of MHC heavy chain and β2-Microglobulin is known to be assembled into the TAP molecule (transporter associated with antigen processing) through interactions with a number of chaperones. Binding of processed peptide releases the Class I-β2-Microglobulin complex to the cell surface. Absence of binding leads to degradation in the proteasome. |
| CAS # | Not applicable |
| Format | Solid |
| Formulation Details | Lyophilized from 0.02 M NH4(HCO3) |
| Pack Size | 500 µg |
| Purity | 30 - 60 % |
| Source | Human Urine |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |